seRNA building blocks

seRNA building blocks

An RNA pro-drug platform technology that can easily be adapted

seRNAs represent a pro-drug platform technology that can easily be adapted to numerous therapeutic areas by utilizing the transcriptome for selective cell targeting and Fusogenic Liposomes for organ specific pre-targeting.

seRNAs can be designed from modular building blocks, creating a platform technology that can be quickly adapted and applied to numerous indications.

seRNAs have a unique mode of action: They enter any cell BUT will only be activated in tumor cells by tumor cell specific RNAs, forming dsRNA with the antisense part of seRNA. seRNA activation results in cell-specific expression of effector molecules in tumor cells only.

efficient Delivery

To deliver seRNAs we are utilizing Fusogenic liposomes (FL)

which allow and enable:

Quick and easy seRNA incorporation

Rapid and efficient cellular uptake

Little endosomal degradation

Organ specific delivery

  • Quick and easy seRNA incorporation

  • Rapid and efficient cellular uptake

  • Little endosomal degradation

  • Organ specific delivery

Cellular uptake &  intracellular activation

seRNAs remain inactive in non-target cells

seRNA activation results in cell-specific expression of effector molecules in tumor cells

Diseased/tumor cell specific expression enables utilization of effector proteins with high(er) efficacy

  1. seRNAs remain inactive in non-target cells
  2. seRNA activation results in cell-specific expression of effector molecules in tumor cells
  3. Diseased/tumor cell specific expression enables utilization of effector proteins with high(er) efficacy

THE seRNA SETUP

seRNAs have a modular set-up and combine RNAi and mRNA

Traditional mRNA, functional domains
seRNA, functional domains
seRNA structure